| Home | Southampton results 2024-2025 |
Southampton's score shown first
| Home | Away |
| 24 Aug | Nottingham Forest | 0-1 | 17 Aug | Newcastle United | 0-1 |
| 14 Sep | Manchester United | 0-3 | 31 Aug | Brentford | 1-3 |
| 21 Sep | Ipswich Town | 1-1 | 30 Sep | Bournemouth | 1-3 |
| 19 Oct | Leicester City | 2-3 | 05 Oct | Arsenal | 1-3 |
| 02 Nov | Everton | 1-0 | 26 Oct | Manchester City | 0-1 |